Studi kasus Leiomoma Apoplektik : Morfologi Tidak Biasa dari Leiomioma yang Menyerupai Keganasan

Authors

  • Silpi Hamidiyah Yarsi University

DOI:

https://doi.org/10.56127/jukeke.v3i3.1651

Keywords:

leiomyoma, apoplectic, mimicking, malignancy

Abstract

Leiomioma apoplektik merupakan tumor jinak mesenkimal asal sel otot polos miometrium yang mengalami perubahan degenerasi hemoragik akibat paparan hormon progesterone. Tidak banyak perhatian yang ditujukan terhadap leiomioma apoplektik, namun tumor ini memiliki spektrum morfologi yang luas dan seringkali menimbulkan kesalahan diagnosis, terutama dengan keganasan. Kami melaporkan kasus seorang wanita usia 34 tahun, postpartum dengan leiomioma uteri multipel yang mengandung fokus nekrotik dan bekuan darah pada bagian sentral. Pendekatan teoritis mengenai leiomioma apoplektik menjadi penting mengingat kemiripan morfologi dari tumor ini dengan leiomyosarcoma dan smooth muscle tumors of uncertain malignant potential yang merupakan diagnosis banding dari neoplasia ini.

References

D’Angelo E, Quade BJ, Prat J. (2014). Uterine Smooth Muscle Tumors in Robboy : pathology of the female reproductive tract. Chapter 19. Churchill Livingstone Elsevier. China. p406.

Bolde SA, Chavhan SV, Rathod AE, et al. Histomorphological Spectrum of Uterine Smooth Muscle Tumors. J South Asian Feder Obst Gynae 2022;14(2):95–100.

Alran L, Rychlik A, Croce S. (2021). Leiomyoma-general. Tersedia secara online di alamat website : https://www.pathologyoutlines.com/topic/uterusleiomyoma.html. Akses pada tanggal 28 Desember 2022.

Bennett JA, Lamb C, Young RH. (2016). Apoplectic Leiomyomas. The American Journal of Surgical Pathology. Vol 40 (4) : 563-568. Doi: 10.1097/PAS.0000000000000569

Tu W, Yano M, Schieda N, Krishna S, Chen L, Gottumukkala RV, et.al., Smooth Muscle Tumors of the Uterus at MRI: Focus on Leiomyomas and FIGO Classification. RadioGraphics, 2023, 43(6). DOI : https://doi.org/10.1148/rg.220161

Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. (1972). Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy". Am. J. Obstet. Gynecol. 112 (8): 1095–100. DOI:10.1016/0002-9378(72)90185-8. PMID 5025870

Greco S, Pinheiro J, et al. Raf kinase inhibitor protein expression in smooth muscle tumours of the uterus: a diagnostic marker for leiomyosarcoma?. RBMO, 2024, 48(6):1-15. DOI : . https://doi.org/10.1016/j.rbmo.2024.103816.

Zannotti A, Greco S, et. Macrophages and immune responses in uterine fibroids. Cells, 2021, 10(5), 982. DOI : https://doi.org/10.3390/cells10050982

Reis FM, Bloise E, Ortiga-Carvalho TM. (2016). Hormones and pathogenesis of uterine fibroids. Best Practice & Research Clinical Obstetrics & Gynaecology, 34, 13–24. doi:10.1016/j.bpobgyn.2015.11.015

Turner, B.M., Cramer, S.F., Heller, D.S. et al. Apoplectic leiomyomas: does ethnicity make a difference? a clinicopathologic study. Virchows Arch 480, 645–654 (2022). https://doi.org/10.1007/s00428-021-03225-z

Budihal N, Pawar JG, Manasa GC. Histomorphological study of uterine leiomyomas and its variants with brief review of literature. Pathology Update: Tropical Journal of Pathology and Microbiology, 2019, 5(7). DOI: https://doi.org/10.17511/jopm.2019.i07.09

Turashvili G. (2021). Smooth muscle tumors of uncertain malignant potential. Tersedia secara online pada alamat website : https://www.pathologyoutlines.com/topic/uterusSTUMP.html. Diakses secara online pada tanggal 11 Januari 2023.

Ip PPC, Croce S, and Gupta M. (2020). Smooth muscle tumors of uncertain malignant potential in WHO classification of tumours Female genital tumours. 5th ed. IARC. 279-80.

Longrace TA, Lim D, and Parra-Herran C. (2020). Uterine Leiomyosarcoma in WHO classification of tumours Female genital tumours. 5th ed. IARC. 283-5.

Mhawech-Fauceglia P. (2021). Leiomyosarcoma. Tersedia secara online pada alamat website : PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uteruslms.html. Diakses secara online pada tanggal 7 September 2022.

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Published

2024-10-31

How to Cite

Hamidiyah, S. (2024). Studi kasus Leiomoma Apoplektik : Morfologi Tidak Biasa dari Leiomioma yang Menyerupai Keganasan. Jurnal Kesehatan Dan Kedokteran, 3(3), 14–18. https://doi.org/10.56127/jukeke.v3i3.1651

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