The Effectiveness of Pharmacist-led Education on Patient Adherence to Medication: A Literature Review

Authors

  • Maghfiroti Fitri Sekolah Tinggi Ilmu Kesehatan Sambas
  • Rusmina Iswanti Kumala Dewi Sekolah Tinggi Ilmu Kesehatan Sambas

DOI:

https://doi.org/10.56127/jukeke.v4i2.2178

Keywords:

pharmacist education, medication adherence, patient counseling, drug use

Abstract

Patient adherence to medication is a critical factor for the success of pharmacological therapy, yet low adherence remains a challenge in many healthcare systems. Pharmacist-led education has emerged as a promising strategy to improve medication adherence. This study aims to assess the effectiveness of pharmacist educational interventions on patient adherence through a literature review approach. A total of 19 national and international articles published in the last 10 years were reviewed. Findings indicate that interventions such as face-to-face counseling, educational booklets, SMS reminders, and training on proper medication use significantly enhance adherence, reduce the risk of complications, and improve patients’ quality of life. These results reinforce the strategic role of pharmacists in delivering patient-centered pharmaceutical care.

References

Aliviyanti, R. U. Y. (2014, December 11). Kepatuhan Pasien: Faktor Penting dalam Keberhasilan Terapi. Https://Uad.Ac.Id/Kepatuhan-Pasien-Faktor-Penting-Dalam-Keberhasilan-Terapi/.

Ardavani, A., Curtis, F., Hopwood, E., Highton, P., Katapa, P., Khunti, K., & Wilkinson, T. J. (2025). Effect of pharmacist interventions in chronic kidney disease: a meta-analysis. Nephrology Dialysis Transplantation, 40(5), 884–907. https://doi.org/10.1093/ndt/gfae221

Ayogu, E. E., Yahaya, R. I., Isah, A., & Ubaka, C. M. (2023). Effectiveness of a pharmacist‐led educational intervention on health outcomes in hypertension management at community pharmacies in Nigeria: A two‐arm parallel single‐blind randomized controlled trial. British Journal of Clinical Pharmacology, 89(2), 649–659. https://doi.org/10.1111/bcp.15514

Besemah, N. A., Sartika, R. A. C., & Sauriasari, R. (2021). Effect of Pharmacist Intervention on Medication Adherence and Clinical Outcomes of Type 2 Diabetes Mellitus Outpatients in Primary Healthcare in Indonesia. Journal of Research in Pharmacy Practice, 9(4), 186–195.

Budiyanti, N. A., Wiedyaningsih, C., & Andayani, T. M. (2022). Pengaruh Konseling Apoteker terhadap Kepatuhan dan Kualitas Hidup Pasien Hipertensi Program Rujuk Balik di Apotek. Majalah Farmaseutik, 18(3), 324. https://doi.org/10.22146/farmaseutik.v18i3.68586

Calleja, L., Glass, B. D., Cairns, A., & Taylor, S. (2023). Pharmacist-Led Interventions for Medication Adherence in Patients with Chronic Kidney Disease: A Scoping Review. Pharmacy, 11(6), 185. https://doi.org/10.3390/pharmacy11060185

Chatha, Z. F., Rashid, U., Olsen, S., Din, F. ud, Khan, A., Nawaz, K., Gan, S. H., & Khan, G. M. (2020a). Pharmacist-led counselling intervention to improve antiretroviral drug adherence in Pakistan: a randomized controlled trial. BMC Infectious Diseases, 20(1), 874. https://doi.org/10.1186/s12879-020-05571-w

Chatha, Z. F., Rashid, U., Olsen, S., Din, F. ud, Khan, A., Nawaz, K., Gan, S. H., & Khan, G. M. (2020b). Pharmacist-led counselling intervention to improve antiretroviral drug adherence in Pakistan: a randomized controlled trial. BMC Infectious Diseases, 20(1), 874. https://doi.org/10.1186/s12879-020-05571-w

Christine, I., & Kristi Layun, M. (2021). GAMBARAN TINGKAT KEPATUHAN PASIEN DALAM MINUM OBAT ANTI HIPERTENSI DI PUSKESMAS AIR PUTIH SAMARINDA. https://repository.unmul.ac.id/bitstream/handle/123456789/22991/GAMBARAN%20TINGKAT%20KEPATUHAN%20PASIEN%20DALAM%20MINUM%20OBAT.pdf?sequence=1&isAllowed=y

Conn, V. S., & Ruppar, T. M. (2017). Medication adherence outcomes of 771 intervention trials: Systematic review and meta-analysis. Preventive Medicine, 99, 269–276. https://doi.org/10.1016/j.ypmed.2017.03.008

Elnaem, M. H., Rosley, N. F. F., Alhifany, A. A., Elrggal, M. E., & Cheema, E. (2020).

Impact of Pharmacist-Led Interventions on Medication Adherence and Clinical Outcomes in Patients with Hypertension and Hyperlipidemia: A Scoping Review of Published Literature

. Journal of Multidisciplinary Healthcare, Volume 13, 635–645. https://doi.org/10.2147/JMDH.S257273

Goruntla, N., Mallela, V., & Nayakanti, D. (2019). Impact of pharmacist-directed counseling and message reminder services on medication adherence and clinical outcomes in type 2 diabetes mellitus. Journal of Pharmacy And Bioallied Sciences, 11(1), 69. https://doi.org/10.4103/JPBS.JPBS_211_18

Hepler, C. D., & Strand, L. M. (1990). Opportunities and responsibilities in pharmaceutical care. American Journal of Hospital Pharmacy, 47(3), 533–543.

Janz, N. K., & Becker, M. H. (1984). The Health Belief Model: A Decade Later. Health Education Quarterly, 11(1), 1–47. https://doi.org/10.1177/109019818401100101

Jasińska-Stroschein, M. (2022). The Effectiveness of Pharmacist Interventions in the Management of Patient with Renal Failure: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 19(18), 11170. https://doi.org/10.3390/ijerph191811170

Jia, X., Zhou, S., Luo, D., Zhao, X., Zhou, Y., & Cui, Y. (2020). Effect of pharmacist‐led interventions on medication adherence and inhalation technique in adult patients with asthma or COPD: A systematic review and meta‐analysis. Journal of Clinical Pharmacy and Therapeutics, 45(5), 904–917. https://doi.org/10.1111/jcpt.13126

Kelly, W. N., Ho, M.-J., Smith, T., Bullers, K., & Kumar, A. (2023). Association of pharmacist intervention counseling with medication adherence and quality of life: A systematic review and meta-analysis of randomized trials. Journal of the American Pharmacists Association, 63(4), 1095–1105. https://doi.org/10.1016/j.japh.2023.04.024

Marcum, Z. A., Jiang, S., Bacci, J. L., & Ruppar, T. M. (2021). Pharmacist‐led interventions to improve medication adherence in older adults: A meta‐analysis. Journal of the American Geriatrics Society, 69(11), 3301–3311. https://doi.org/10.1111/jgs.17373

Nguyen, T., Nguyen, T. H., Nguyen, P. T., Tran, H. T., Nguyen, N. V., Nguyen, H. Q., Ha, B. N., Pham, T. T., & Taxis, K. (2018). Pharmacist-Led Intervention to Enhance Medication Adherence in Patients With Acute Coronary Syndrome in Vietnam: A Randomized Controlled Trial. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00656

Peraturan Menteri Kesehatan Nomor 73 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Apotek. (2017, January 9). Https://Peraturan.Bpk.Go.Id/Details/114626/Permenkes-No-73-Tahun-2016.

Puji Astuti, S., Saibi, Y., & Dasuki, A. (2018). PELAYANAN KONSELING PASIEN OLEH APOTEKER DI KOTA MEDAN PATIENT COUNCELING SERVICE BY PHARMACIST IN MEDAN CITY 1 2 3. https://doi.org/https://doi.org/10.22236/farmasains.v5i1.3630

Putman, B., Coucke, L., Vanoverschelde, A., Mehuys, E., & Lahousse, L. (2022). Community pharmacist counseling improves adherence and asthma control: a nationwide study. BMC Health Services Research, 22(1), 112. https://doi.org/10.1186/s12913-022-07518-0

Readdean, K. C., Heuer, A. J., & Scott Parrott, J. (2018). Effect of pharmacist intervention on improving antidepressant medication adherence and depression symptomology: A systematic review and meta-analysis. Research in Social and Administrative Pharmacy, 14(4), 321–331. https://doi.org/10.1016/j.sapharm.2017.05.008

Rubio-Valera, M., Serrano-Blanco, A., Magdalena-Belío, J., Fernández, A., García-Campayo, J., March Pujol, M., & López del Hoyo, Y. (2011). Effectiveness of Pharmacist Care in the Improvement of Adherence to Antidepressants: A Systematic Review and Meta-Analysis. Annals of Pharmacotherapy, 45(1), 39–48. https://doi.org/10.1345/aph.1P429

Suci, R. P., Saibi, Y., & Dasuki, A. (2018). Kualitas Pelayanan Informasin Obat (Konseling) di Apotek Kabupaten Garut. Jurnal Pharmascience, 5(1). https://doi.org/10.20527/jps.v5i1.5779

Syifannisa, R., Muthoharoh, A., Ningrum, W. A., & Rahmatullah, S. (2022). Pengaruh Konseling Apoteker Terhadap Kepatuhan Pengobatan dan Outcome Klinis Pasien DM Tipe 2 Puskesmas Mulyoharjo. Jurnal Ilmiah Kesehatan, 15(2), 93–102. https://doi.org/10.48144/jiks.v15i2.1127

Undang-Undang Nomor 17 Tahun 2023 tentang Kesehatan. (2023). https://peraturan.bpk.go.id/Details/258028/uu-no-17-tahun-2023

Yuliana, V., Setiadi, A. P., & Ayuningtyas, J. P. (2019). Efek Konseling Apoteker Terhadap Kepatuhan Minum Obat dan Kualitas Hidup Penderita Skizofrenia di Rumah Sakit Jiwa Menur Surabaya. Indonesian Journal of Clinical Pharmacy, 8(3). https://doi.org/10.15416/ijcp.2019.8.3.196

Zhao, Y.-Y., Dang, F.-P., Zhai, T.-T., Li, H.-J., Wang, R.-J., & Ren, J.-J. (2019). The effect of text message reminders on medication adherence among patients with coronary heart disease. Medicine, 98(52), e18353. https://doi.org/10.1097/MD.0000000000018353

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Published

2025-07-23

How to Cite

Fitri, M., & Dewi, R. I. K. (2025). The Effectiveness of Pharmacist-led Education on Patient Adherence to Medication: A Literature Review. Jurnal Kesehatan Dan Kedokteran, 4(2), 58–70. https://doi.org/10.56127/jukeke.v4i2.2178

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