Literature Review: Hypogonadism in Men
DOI:
https://doi.org/10.56127/jukeke.v4i3.2339Keywords:
Hypogonadism, Testosterone, Men, Quantitative Methods, Erectile Dysfunction, Hormones, Reproductive HealthAbstract
Male hypogonadism is a medical condition characterized by reduced testosterone production due to disorders of the testes or the hypothalamic–pituitary axis. This study employs a quantitative approach to systematically review the literature on the prevalence, risk factors, and physiological and psychological impacts of hypogonadism in men. Data were drawn from clinical and observational studies published over the past four years that analyzed associations among testosterone levels, age, body mass index, and symptoms such as erectile dysfunction and decreased libido. The review indicates that hypogonadism is more common in men over 40 years of age, particularly those with obesity or metabolic disease. Beyond sexual function, the condition also affects muscle mass, bone density, and emotional balance. In conclusion, early detection and appropriate testosterone replacement therapy play an important role in improving quality of life and preventing long-term complications in men with hypogonadism.
References
Ali O, Donohoue PA. Hypofunction of the testes. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM. (2020). eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020
Batmomolin, Agnes. (2023). Anthology of the Pathophysiology of the Endocrine System. Media Pustaka Indo, 124-125
Duarsa, N. M. M. S. B., Purnama, R. F. N., Khalda, Y. I., & Triani, E. (2023). Pathophysiology and Clinical Manifestations of Hypogonadism. Journal of Tropical Biology, 23(1), 535-541.
Gloria Kang GJ, Ewing-Nelson SR, Mackey L, Schlitt JT, Marathe A, Abbas KM, S. S. (2018).Extraction of neonatal rat myocardium HHS Public Access. Physiology & Behavior, 176(1), 139–148. https://doi.org/10.1038/s41572-019-0087-y.Paediatric
Hall, John E; Guyton, Arthur C. (2019). Guyton and Hall: Textbook of Medical Physiology (13). Singapore: ELSEVIER.
Ide, V., Vanderschueren, D., & Antonio, L. (2020). Treatment of men with central hypogonadism: alternatives for testosterone replacement therapy. International Journal of Molecular Sciences, 22(1), 21.
Indirli, R., Lanzi, V., Arosio, M., Mantovani, G., & Ferrante, E. (2023). The association of hypogonadism with depression and its treatments. Frontiers in Endocrinology, 14, 1198437.
Marcdante, K. J., Kliegman, R., Jenson, H. B., Behrman, R. E. (2021). Nelson Essential Pediatrics. Singapore: Elsevier Health Sciences.
Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon JB, Chiles KA, Lightner DJ, Miner MM, Murad MH, Nelson CJ, Platz EA, Ramanathan LV, Lewis RW. (2018). Evaluation and Management of Testosterone Deficiency: AUA Guidelines. J Urol. ; 200 (2):423-432.
Oiseth S, Jones L., and Maza E. (2022). Hypogonadism.
Richard-Eaglin, A. (2018). Male and Female Hypogonadism. Nursing Clinics of North America, 53(3), 395–405. doi:10.1016/j.cnur.2018.04.006
Russ S, Anastasopoulou C, Shafiq I. Pituitary Adenoma. [Updated 2023 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554451
Rahayu, Sri, Trinil Susilawati, Aris Soewondo. (2020). Reproductive Biology: Cellular and Molecular Studies. Brawijaya University Press.
Sherwood, Lauralee. (2018). Human physiology from cells to systems (9th ed.) (Ninth Edition). Jakarta: EGC.
Sizar O, Leslie SW, Schwartz J. (2024). Male Hypogonadism. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available at: https://www.ncbi.nlm.nih.gov/books/NBK532933/













