Association Between Anti-Tuberculosis Drug (OAT) Adherence and Tuberculosis Recurrence Among Pulmonary TB Patients at Dr. Pirngadi Regional Hospital, Medan

Authors

  • Metia Ariani Br Ginting Universitas Muhammadiyah Sumatera Utara, Indonesia
  • Heppy Jelita Sari Batubara Universitas Muhammadiyah Sumatera Utara, Indonesia
  • Hapsah Hapsah Universitas Muhammadiyah Sumatera Utara, Indonesia
  • Mila Trisna Sari Universitas Muhammadiyah Sumatera Utara, Indonesia

DOI:

https://doi.org/10.56127/jukeke.v5i1.2582

Keywords:

Pulmonary Tuberculosis, Anti-Tuberculosis Drugs, Medication Adherence, Recurrence.

Abstract

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major public health problem. Treatment success depends heavily on adherence to anti-tuberculosis drug (ATD) therapy; however, the long treatment duration may reduce adherence and increase the risk of recurrence. Objective: This study aimed to describe the demographic characteristics of pulmonary TB patients and to analyze the association between adherence to ATD therapy and TB recurrence at Dr. Pirngadi General Hospital, Medan. Methods: A quantitative observational analytic study with a cross-sectional design was conducted among 33 pulmonary TB patients treated at Dr. Pirngadi General Hospital, Medan (November–December 2025). Data were collected using an ATD adherence questionnaire and complemented with medical record data. Descriptive statistics were used to summarize patient characteristics, adherence levels, and recurrence status, while the Chi-square test was applied to assess the association between adherence and recurrence (p < 0.05). Results: Most respondents exhibited low adherence to ATD therapy (66.7%), and a high proportion experienced TB recurrence (78.8%). The majority were male (51.5%), predominantly in the adult age group (41–60 years; 51.5%), had a senior high school education (87.9%), and were self-employed. A statistically significant association was found between adherence to ATD therapy and TB recurrence (p = 0.046). Implications: These findings reinforce the need to strengthen adherence-support strategies in hospital TB services, including structured counseling, active follow-up, and family or treatment supervisor involvement, to reduce recurrence risk and improve program outcomes. Originality/Value: This study provides facility-based evidence from Dr. Pirngadi General Hospital, Medan, demonstrating a significant relationship between adherence level and recurrence status, offering locally relevant data to guide targeted adherence interventions and recurrence prevention in hospital settings.

References

Afrianti, R., Larucy, F., & Widayana, H. (2023). Interaksi obat anti tuberkulosis pada pasien tuberkulosis paru. Jurnal Kesehatan Perintis (Perintis’s Health Journal), 10(1), 53–59. https://doi.org/10.33653/jkp.v10i1.912

Ahdiyah, N. N., Andriani, M., & Andriani, L. (2022). Tingkat kepatuhan penggunaan obat anti tuberkulosis pada pasien TB paru dewasa di Puskesmas Putri Ayu. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 3(1), 23. https://doi.org/10.31764/lf.v3i1.6817

Amalia, A., Arini, H. D., & Dhrik, M. (2022). Analysis of the relationship of compliance rate of antituberculosis drug on the quality of life of lung tuberculosis patients. Jurnal Ilmiah Mahaganesha, 1(2), 67–74.

Amran, R., & Abdulkadir, W. M. (2021). Tingkat kepatuhan penggunaan obat anti tuberkulosis pada pasien di Puskesmas Tombulilato Kabupaten Bone Bolango. Indonesian Journal of Pharmaceutical Education, 1(1), 57–66. https://doi.org/10.22487/ijpe.v1i1.101223

Avy, A. H., Hutami, B. P., Alfalah, M. Z., & Febriyanti, S. (2024). Faktor risiko kejadian tuberkulosis paru di berbagai wilayah Indonesia. 11(1), 61–65.

Dhanny, D. R., & Sefriantina, S. (2022). Hubungan asupan energi, asupan protein, dan status gizi terhadap kejadian tuberkulosis pada anak. Muhammadiyah Journal of Nutrition and Food, 2(2), 58–68. https://doi.org/10.24853/mjnf.2.2.58-68

Fauzia, D., Gunawan, A. R. S., & Simbolon, R. L. (2017). Kepatuhan pasien terhadap pengobatan tuberkulosis paru di lima puskesmas se-Kota Pekanbaru. 4(2), 1–20.

Kementerian Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/755/2019 tentang pedoman nasional pelayanan kedokteran tata laksana tuberkulosis. Kementerian Kesehatan RI.

Kusmiyani, O. T. (2024). Analisis faktor yang berhubungan dengan kepatuhan minum obat anti tuberkulosis pada pasien TB paru di Puskesmas Samuda dan Bapinang Kotawaringin Timur.

Nabila, N. (2023). Faktor-faktor yang mempengaruhi kepatuhan minum obat anti tuberkulosis (OAT) pada penderita tuberkulosis paru: Literature review. Media Publikasi Promosi Kesehatan Indonesia, 6(8), 1478–1484. https://doi.org/10.56338/mppki.v6i8.3484

Nopita, E., Suryani, L., & Siringoringo, H. E. (2023). Analisis kejadian tuberkulosis (TB) paru. Jurnal Kesehatan Siliwangi Putra, 6(1). https://doi.org/10.32524/jksp.v6i1.827

Penelitian, U., Politeknik, M., Ar, A., & Novitry, F. (2024). Faktor-faktor yang berhubungan dengan kepatuhan berobat TB paru. 20, 139–153.

Setyaningrum, T. A., Carolia, N., Ramadhian, M. R., et al. (2023). Peran pengawas menelan obat (PMO) terhadap pengobatan penderita tuberkulosis (TB): Literature review. 10(3), 20–25.

Society, J. H. (2025). Hubungan dukungan keluarga dengan kepatuhan minum obat pada pasien tuberkulosis paru. 14(2), 112–120. https://doi.org/10.62094/jhs.v14i2.241

Sains, J. K. (2023). Analisis faktor risiko tingginya kasus tuberkulosis paru di Indonesia: Literature review. 6(5), 469–476.

Rosadi, D. (n.d.). Faktor-faktor yang berhubungan dengan kepatuhan pasien tuberkulosis paru terhadap obat anti tuberkulosis, 80–84.

Penentu, F., Minum, K., & Penderita, O. (2024). Faktor penentu kepatuhan minum obat penderita tuberkulosis. 6604(3), 242–252.

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Published

2026-02-13

How to Cite

Ginting, M. A. B., Batubara, H. J. S., Hapsah, H., & Sari, M. T. (2026). Association Between Anti-Tuberculosis Drug (OAT) Adherence and Tuberculosis Recurrence Among Pulmonary TB Patients at Dr. Pirngadi Regional Hospital, Medan. Jurnal Kesehatan Dan Kedokteran, 5(1), 357–370. https://doi.org/10.56127/jukeke.v5i1.2582

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