Platelet Lymphocyte Ratio (Prl) And Grace (Global Registry Of Acute Coronary Events) Score As Prognostic Indicators Of Mortality In Acute Coronary Syndrome
DOI:
https://doi.org/10.56127/jukim.v4i6.2328Keywords:
ACS, PRL, GRACE Score.Abstract
Inflammation plays a crucial role in the early stages of atherosclerosis, which can then trigger acute coronary syndrome. Acute coronary syndrome (ACS) is a potentially fatal condition. Therefore, accurate predictive tools are needed to estimate mortality risk, allowing for more appropriate patient management. One commonly used method is the GRACE (Global Registry of Acute Coronary Events) score. Several studies have shown that combining the GRACE score with clinical and laboratory parameters can improve the accuracy of mortality prediction in ACS patients. In this regard, an easily obtained and assessed inflammatory indicator. the Platelet-Lymphocyte Ratio (PRL), can be an effective tool. This study is observational analytics with a retrospective approach. This study included 98 patients with a diagnosis of ACS based on medical record data. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS). P-value <0.05 was considered statistically significant. A chi-square statistical test was performed on mortality rate (p-value=<0.001). The same test was performed on the Grace score on mortality (p-value=<0.001). These findings indicate that both RPL and GRACE score can be used as effective prognostic indicators of mortality in patients with acute coronary syndrome.
References
[1] S. S. Virani et al., “Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association,” Circulation, vol. 141, no. 9, Mar. 2020, doi: 10.1161/CIR.0000000000000757.
[2] who.int, “Cardiovascular diseases (CVDs),” who.int. Accessed: Apr. 22, 2024. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
[3] World Heart Federation.org, “World Heart Observatory,” World Heart Federation.org. Accessed: Apr. 22, 2024. [Online]. Available: https://world-heart-federation.org/world-heart-observatory/countries/indonesia/
[4] K. Tscherny et al., “Risk stratification in acute coronary syndrome: Evaluation of the GRACE and CRUSADE scores in the setting of a tertiary care centre.,” Int J Clin Pract, vol. 74, no. 2, p. e13444, Feb. 2020, doi: 10.1111/ijcp.13444.
[5] M. Shuvy et al., “Accuracy of the Global Registry of Acute Coronary Events (GRACE) Risk Score in Contemporary Treatment of Patients With Acute Coronary Syndrome.,” Can J Cardiol, vol. 34, no. 12, pp. 1613–1617, Dec. 2018, doi: 10.1016/j.cjca.2018.09.015.
[6] M. S. Awan, M. Y. Daud, M. Khan, A.-U.-R. Jehangiri, Adnan, and S. Jalil, “Usefulness Of Neutrophils To Lymphocytes Ratio For Predicting Troponin-I Elevation In Patients Presenting With Suspected Nste-Acute Coronary Syndrome.,” J Ayub Med Coll Abbottabad, vol. 31(Suppl 1), no. 4, pp. S674–S677, 2019.
[7] D. Zhou et al., “Platelet-to-Lymphocyte Ratio Improves the Predictive Power of GRACE Risk Score for Long-Term Cardiovascular Events in Patients with Acute Coronary Syndrome.,” Cardiology, vol. 134, no. 1, pp. 39–46, 2016, doi: 10.1159/000442939.
[8] B. Y. Siregar, R. Hasan, and R. Isnanta, “Association of Platelet Lymphocyte Ratio (PLR) and Neutrophil Lymphocyte Ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) Score in Acute Coronary Syndrome,” International Journal of Research and Review, vol. 8, no. 5, pp. 1–6, May 2021, doi: 10.52403/ijrr.20210501.
[9] N. Anthony et al., “Age-Related Patterns of Symptoms and Risk Factors in Acute Coronary Syndrome (ACS): A Study Based on Cardiology Patients’ Records at Rehman Medical Institute, Peshawar,” Cureus, Apr. 2024, doi: 10.7759/cureus.58426.
[10] A. Korespondensi, H. Alvenus Willim, S. Prayogi Pakpahan, E. Suprihatin, A. Agustyana, and D. Gusti Arilaksono, “Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Global Registry of Acute Coronary Events Risk Score in Acute Myocardial Infarction.”
[11] B. Mulyana, Y. T. Wahyuningsih, A. Nur’eani, and D. Ekawaty, “KARAKTERISTIK PASIEN SINDROM KORONER AKUT DI INTENSIVE CARDIAC CARE UNIT RSUD TARAKAN JAKARTA,” Indonesian Journal of Nursing Health Science ISSN, vol. 7, no. 2, pp. 105–111, 2022.
[12] T. M. Nguyen et al., “Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study,” J Clin Med, vol. 12, no. 20, p. 6598, Oct. 2023, doi: 10.3390/jcm12206598.
[13] H. Harun, U. Bahrun, and D. ER, “PLATELET-LYMPHOCYTE RATIO (PLR) MARKERS IN ACUTE CORONARY SYNDROME (Platelet Lymphocyte Ratio (PLR) sebagai Petanda Sindrom Koroner Akut),” INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, vol. 23, no. 1, pp. 7–11, Apr. 2018, doi: 10.24293/ijcpml.v23i1.1176.
[14] D. Kumar et al., “Prognostic value of GRACE score for in-hospital and 6 months outcomes after non-ST elevation acute coronary syndrome,” The Egyptian Heart Journal, vol. 73, no. 1, p. 22, Dec. 2021, doi: 10.1186/s43044-021-00146-9.
[15] E. Abu-Assi, J. M. García-Acuña, C. Peña-Gil, and J. R. González-Juanatey, “Validation of the GRACE Risk Score for Predicting Death Within 6 Months of Follow-Up in a Contemporary Cohort of Patients With Acute Coronary Syndrome,” Revista Española de Cardiología (English Edition), vol. 63, no. 6, pp. 640–648, Jan. 2010, doi: 10.1016/S1885-5857(10)70138-9.
[16] E. Ayhan et al., “Patients with anemia on admission who have undergone primary angioplasty for ST elevation myocardial infarction,” Coron Artery Dis, vol. 22, no. 6, pp. 375–379, Sep. 2011, doi: 10.1097/MCA.0b013e3283472ac5.
[17] W. Li, Q. Liu, and Y. Tang, “Platelet to lymphocyte ratio in the prediction of adverse outcomes after acute coronary syndrome: a meta-analysis.,” Sci Rep, vol. 7, p. 40426, Jan. 2017, doi: 10.1038/srep40426.
